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Biophysics of Systems (Master) – Übersicht

  • Übersicht

Informationen zur Vorlesung

Zeit und Ort

Monday 14.00 - 17.30 in presence N020 Kleiner Physikhörsaal

We will explore the physics of biological systems, including their origin, evolution, pattern formation, embryogenesis, biochemical networks, chemotaxis, gene regulation, high throughput methods, neural networks and game theory. The lecture will include a short introduction to reaction-diffusion systems with Comsol. It is a 3 hour lecture, 1 hour seminar, 6 Credit Points - we can offer only the lecture for 4 credit points). The lecture is for Master students, open to other discilines and background on Cellular Biophysics, Molecular Biophysics and Theoretical Biophysics is helpful and recommended. Lecture is within the Biophysics Program of the Physics Master.

Please note that as of 29.11., we switch the lecture to hybrid and offer it again also online (Zoom link), not that the LMU Cast from last year's lecture is still availlable. Likely we will not record the lecture in the hybrid form.

18.10. Introduction to Biophysics of Systems (Slides)

From Evolution to (Synthetic) Biology. Introduction to the topic and the lecture.
Presentation of Seminar Topics - Seminar papers with pwd below.

25.10. How all began: the Emergence of Life (Slides)

Darwin and the phyolgenetic tree. Common strategies of life. Early evolution. Timeline of evolution. Chemical evolution: building blocks. Places for the origin of life. Hydrothermal chemistry. No Seminar.

8.11., 15.11., 22.11.,29.11., How all began: the Emergence of Life

Hydrothermal chemistry. Achaea. Hydrothermal accumulation. Convective PCR. Population Dynamics. Limited growth. Competition for food. Predator-Prey model. Eigen-Model of Molecular evolution. Error threshold. Oxygen crisis. Endosymbiotic development of eucaryotes.
8.11. Seminar: #8 Next gen sequencing   Zsófia Meggyesi, Karl Heggenberger
15.11./22.11. Seminar: #6, Sandro Paetzold & Leonard Rosemann
29.11. No Seminar

06.12. Bacterial Chemotaxis

Locomotion of E-Coli, directional movement, run and tumble, Che-Protein network, adaptation, Sensitivity, Cooperative Binding, Hill equation, Konformation model of receptor, Ising model of receptor field, Boolean Algebra within receptor fields.
Seminar: #13 Light sheet microscopy Lara Kunze, Isabella Tepfenhart

13.12. Chemotaxis of Eukaryotes

Chemotaxis of Dictyostelia. Outlook: Chemotaxis in Brain development.
Seminar: #11 Kinetic sequencing, Bao Tai

20.12. Pattern formation, Hydra, Embryogenesis

Biological pattern formation and morphogenesis. Activator-Inhibitor models. Structure formation in space and time. Oscillating reactions. Hydra.
Seminar: #2 Benedikt Müller, Stefanelli Federico

10.1. Gene regulation and Stochastic Genes

Regulation circuitry of protein expression.
Seminar: #2 Benedikt Müller, Stefanelli Federico

17.1. Modeling of Reaction-Diffusion Systems with Comsol

Introduction to the finite element modelling of reaction-diffusion systems with examples from Embryogenesis and reaction oscillation systems. Simulations will be programmed in Comsol, with the possibility for hands on programming on your notebook.
Seminar: #10 Frischmann, Theis

24.1. Neural Networks

Basics Models and physiological Basis of Neural networks
Seminar: #28 Achim Brinkop, Girnar Goyal

31.1. Game theory and evolution

Description of economic processes, application in population dynamics
Seminar: #4 Lara S. Anubis

7.2. Oral Exams

 

Exams: The exam times are discussed and set in the lecture. They will be oral exams.
Please send your bring your filled out "Schein" to the exam. You can download the prefilled Schein here.

pwd: evolution21

Verantwortlich für den Inhalt: Dieter Braun